* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
PBS, pH 7.4,
0.09% sodium azide
Product Specific Information
PA5-16634 targets von Willebrand Factor in IF and IHC (P) applications and shows reactivity with Human samples.
The PA5-16634 immunogen is purified factor VIII related antigen/von Willebrand factor.
Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. von Willebrand factor is synthesized by endothelial cells and stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial (or megakaryocytic) lineage of neoplasms. As not all endothelial cells synthesize/ store) this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence.
von Willebrand Factor Antibody (PA5-16634) in IHC PA5-16634_Immunohistochemistry.jpg
Immunohistochemistry with anti-von Willebrand Factor Polyclonal Antibody (PA5-16634)