* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
-20° C, Avoid Freeze/Thaw Cycles
Product Specific Information
In Western blot, bands are observed at ~100 kDa and ~200 kDa representing the monomer and dimer forms of WFS1.
Suggested positive control: antigen standard for WFS1 (transient overexpression lysate).
WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.
WFS1 Antibody (PA1-16923) in WB PA1-16923_Westernblot.jpg
Western Blot with anti-WFS1 Polyclonal Antibody (PA1-16923)