TNF Alpha Antibody
TNF Alpha Polyclonal Antibody for ELISA, Western blot
Synonyms:
TNF-a; TNF-alpha; cachectin; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor, alpha (TNF superfamily, member 2)
Entrez Gene ID:
UniProt ID:
Q06599
| Details | |
| Host / Isotype: | Rabbit / IgG |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Bovine (Bv) |
| Immunogen: | TNF alpha |
| Ordering Information | ||||
| Pierce TNF Alpha Antibody |
| Storage: | 4° C |
| Form: | 1 mg of purified antibody by Protein G affinity chromatography and Lyophilized in preservative and carrier free PBS. |
| Applications | Dilution * |
| ELISA (ELISA) | Assay Dependent |
| Western Blot (WB) | Assay Dependent |
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* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
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| Product Specific Information |
| PBOTNFAI targets TNF Alpha in ELISA, and WB applications and shows reactivity with Bovine samples. The PBOTNFAI immunogen is tNF alpha. PBOTNFAI detects TNF Alpha which has a predicted molecular weight of approximately 26 kDa. |
| General Information |
| This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
| PubMed References: |
| Western Blot | ||
| Species / Dilution | Summary | |
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Bv / Not Cited |
PBOTNFAI was used in western blot to investigate the involvement of the NF-kB pathway and TNF-alpha in the cytotoxicity of anthrax lethal toxin
Vet Microbiol. 2010 Nov 20;146(1-2):111-7.
"Activation of NF-?B pathway and TNF-? are involved in the cytotoxicity of anthrax lethal toxin in bovine BoMac macrophages." Author(s): Liang X, Gao CF, Rutherford MS, Ji Y Number of Citations: 0 (See PubMed article  )
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(This product is for In Vitro experimental use only. Not for resale without express authorization.)
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TNF Alpha Antibodies > TNF Alpha Polyclonal Antibody PBOTNFAI
