TLR7 Antibody

TLR7 Polyclonal Antibody for IHC (P), Western blot

Entrez Gene ID:

UniProt ID:

(Hu) Q9NYK1

Details

Host / Isotype:	Rabbit / IgG
Class:	Polyclonal
Type:	Antibody
Species Reactivity:	Human (Hu) Mouse (Ms)
Immunogen:	Synthetic peptide, conjugated to KLH, corresponding to residues Y(465)FRYDKYARSCRFKNKEAS(483) of human TLR7.

Ordering Information
Pierce TLR7 Antibody

Product #

PA1-20817

Size

100 µl

Price

$354.00

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Storage:	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:	100 ul of Protein G purified antibody in PBS with 0.2% gelatin and 0.05% sodium azide.

Applications	Dilution *

Western Blot (WB)	1:500 - 1:1000
Immunohistochemistry (Paraffin) (IHC (P))	1:100
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Product Specific Information

PA1-20817 detects TLR7 in human, rat and mouse samples.

PA1-20817 has been successfully used in immunohistochemistry (paraffin) and Western Blot procedures.

The PA1-20817 immunogen ynthetic peptide, conjugated to KLH, corresponding to residues Y(465)FRYDKYARSCRFKNKEAS(483) of human TLR7. This sequence is 100% conserved in mouse and rat TLR7.

General Information

The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL 1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1 10) have been described. Stimulation of the NFkB signaling pathway by TLR7 suggests that it plays a role in immune response.

(This product is for In Vitro experimental use only. Not for resale without express authorization.)