SDHB Antibody

SDHB Polyclonal Antibody for Western blot, IF, ICC, IHC (P)

>> See 3 other antibodies for SDHB (IP, PGL4, SDH, SDH1, SDH2, SDHIP, iron-sulfur subunit of complex II, succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial)
Synonyms:
IP, PGL4, SDH, SDH1, SDH2, SDHIP, iron-sulfur subunit of complex II, succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Entrez Gene ID:
UniProt ID:
Details
Host / Isotype: Rabbit
Class: Polyclonal
Type: Antibody
Tested Species Reactivity: Human (Hu), Mouse (Ms)
Immunogen: A synthetic peptide made to an N-terminal region of the human SDHB protein (within residues 1-150).
Ordering Information
Pierce SDHB Antibody
Product #
PA5-23079
Size
100 ul
Price
$316.00
Purchase
Add SDHB Antibody to your cart.
Tested Applications Dilution *
Western Blot (WB) 1:7000
Immunofluorescence (IF) 1:50-1:100
Immunocytochemistry (ICC) 1:50-1:100
Immunohistochemistry (Paraffin) (IHC (P)) 1:50-1:100
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Form Information
Form: Liquid
Concentration: 0.57mg/ml
Purification: Antigen affinity chromatography
Storage Buffer: PBS with 30% glycerol
Preservative: 0.05% sodium azide
Storage Conditions: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Specific Information
The target sequence has 92% sequence homology with rat, bovine and porcine, 85% sequence homology with xenopus and 84% sequence homology with zebrafish.
General Information
Part of the succinate dehydrogenase complex, SDHB is a mitochondrial protein that interfaces with the catalysis of succinate dehydrogenase. In many gastrointestinal tumors, SDHB is irregularly expressed, and leads to mutational activation of KIT. This may be as a result of elevated oxidative stress caused by mitochondrial dysfunction. In Dutch populations, there is a higher prevalence of mutations in the SDHB gene, and a higher overall level of hereditary paraganglioma and pheochromocytoma syndromes than in other Europeans. Similar trends in mutations in this gene seem to be related to atherosclerosis in American populations. Overall, the SDHB protein effects multiple cellular metabolism processes and it is not surprisingly linked to metabolism-related cellular dysfunctions.
Product Images
  • SDHB Antibody (PA5-23079) in WB
    PA5-23079_WesternBlot.jpg

    Western Blot with anti-SDHB Polyclonal Antibody (PA5-23079) (PA5-23079_WesternBlot.jpg)

    Western Blot with anti-SDHB Polyclonal Antibody (PA5-23079)

  • SDHB Antibody (PA5-23079) in IF
    PA5-23079_Immunofluorescence.jpg

    Immunofluorescence with anti-SDHB Polyclonal Antibody (PA5-23079) (PA5-23079_Immunofluorescence.jpg)

    Immunofluorescence with anti-SDHB Polyclonal Antibody (PA5-23079)

  • SDHB Antibody (PA5-23079) in IHC
    PA5-23079_Immunohistochemistry.jpg

    Immunohistochemistry with anti-SDHB Polyclonal Antibody (PA5-23079) (PA5-23079_Immunohistochemistry.jpg)

    Immunohistochemistry with anti-SDHB Polyclonal Antibody (PA5-23079)

(This product is for In Vitro experimental use only. Not for resale without express authorization.)
Part of Thermo Fisher Scientific