RET transforming sequence, cadherin family member 12, cadherin-related family member 16, hydroxyaryl-protein kinase, proto-oncogene c-Ret, proto-oncogene tyrosine-protein kinase receptor Ret, receptor tyrosine kinase, ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
tissue culture supernatant
0.09% sodium azide
Product Specific Information
MA5-11513 targets Ret Oncoprotein in IHC (P) applications and shows reactivity with Human samples.
The MA5-11513 immunogen is recombinant protein encoding the extreme C-terminal cytoplasmic region of the human ret oncoprotein.
The ret proto-oncogene encodes a cell surface glycoprotein belonging to a member of the receptor tyrosine kinase family and is located on chromosome 10q11.2. Three main 3' splice isoforms have been characterized from papillary thyroid carcinomas, themselves originating from thyroid epithelial cells. Ret expression is observed in several regions of the central nervous system; in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuroretina and the growing tips of the renal collecting ducts in developing kidney.
Ret Oncoprotein Antibody (MA5-11513) in IHC MA5-11513_Immunohistochemistry.jpg
Immunohistochemistry with anti-Ret Oncoprotein Monoclonal Antibody [3F8] (MA5-11513)
Formalin-fixed, paraffin-embedded human small intestine stained with ret Oncoprotein antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of neurons of myenteric nerve plexus.
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