Part of Thermo Fisher Scientific

Prothymosin alpha-1 Polyclonal Antibody

Prothymosin alpha-1 Antibody for ELISA

Synonyms:
MGC104802, TMSA
Entrez Gene ID:
(Human) 5757
UniProt ID:
P06454
Details
Host / Isotype: Rabbit
Class: Polyclonal
Type: Antibody
Species Reactivity: Human (Hu) Rat (Rt) Bovine (Bv)
Immunogen: Synthetic peptide of human prothymosin alpha 1 domain.
Ordering Information
Pierce Prothymosin alpha-1 Polyclonal Antibody
Product Number Pkg. Size Price Purchase
GB-30019 250 µl $325.00
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This product is not available outside of the U.S.

Storage: 4º C
Form: 250 µl of antibody provided as lyophilized powder. Redissolve the powder with 250 microliter sterile water to restore to the original concentration (1×PBS).


Applications Dilution *
ELISA (ELISA) 1:5,000
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Product Specific Information
GB-30019 detects Prothymosin alpha 1 in human, rat and bovine samples.

GB-30019 has been successfully used in ELISA procedures.

The GB-30019 immunogen is a synthetic peptide located within the N-terminal half of human prothymosin alpha 1 domain.

Store at 4ºC short term. For long term storage, aliquot and store at -20ºC.
General Information
The thymus gland produces several hormones or hormone-like substances which are derived from a polypeptide precursor containing (in the rat) 113 amino acids and known as prothymosin-alpha. A peptide containing 28 amino acid residues, named thymosin-alpha-1, was originally isolated from calf thymosin fraction 5 and shown to restore various aspects of immune function in several in vitro and invivo test systems. Thymosin-alpha-1 was subsequently isolated from a similar fraction from human thymosin and reported to have the same amino acid sequence as bovine thymosin-alpha-1. In 2003, Jiang et al. identified a pathway that regulates mitochondria-initiated caspase activity. In this pathway, putative human HLA class II-associated protein (PHAP) promoted caspase-9 activation after apoptosome formation, whereas prothymosin-alpha-1 negatively regulated caspase-9 activation by inhibiting apoptosome formation.
(This product is for In Vitro experimental use only. Not for resale without express authorization.)