Part of Thermo Fisher Scientific

Protein Tyrosine Phosphatase 3 Polyclonal Antibody

Protein Tyrosine Phosphatase 3 Antibody for ELISA, Western blot

Synonyms:
HPTPG, PTPG, R-PTP-GAMMA, RPTPG
Entrez Gene ID:
(Human) 5793
UniProt ID:
P23470
Details
Host / Isotype: Rabbit
Class: Polyclonal
Type: Antibody
Species Reactivity: Human (Hu)
Immunogen: Purified recombinant Human PRL-3 protein.
Ordering Information
Pierce Protein Tyrosine Phosphatase 3 Polyclonal Antibody
Product Number Pkg. Size Price Purchase
GB-10343 250 µl $293.00
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This product is not available outside of the U.S.

Storage: -20º C, Avoid Freeze/Thaw Cycles
Form: 250 μl of antibody provided as antiserum. Dissolve the lyophilized product with 0.25 ml sterile water to restore its original concentration.


Applications Dilution *
Western Blot (WB) 1:5,000
ELISA (ELISA) 1:10,000
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Product Specific Information
GB-10343 detects Protein tyrosine phosphatase-3 in human samples.

GB-10343 has been successfully used in Western blot and ELISA procedures.

The GB-10343 immunogen is a recombinant human PRL-3 protein.
General Information
PRL-3 is a newly identified metastasis-related gene, which codes a 22 KDa non-classical protein tyrosine phosphatase with a C-terminal prenylation motif. It is located at the cytoplasmic membrane when prenylated and in the nucleus when nonpreylated. PRL-3 has at least 75% amino-acid sequence similarity with PRL-1 and PRL-2, the other two members of the PRL family. Recently, Zeng and colleagues found that Chinese hamster ovary cells stably expressing PRL-3 exhibited enhanced motility, invasive activity, and induced metastatic tumor formation in nude mice. And in clinical study, PRL-3 is consistently overexpressed in liver metastasis in colorectal cancer cells. These findings suggest PRL-3 is a new target for the early diagnosis of metastasis as well as the drug discovery.
(This product is for In Vitro experimental use only. Not for resale without express authorization.)