* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
PBS, pH 7.4,
0.09% sodium azide
Product Specific Information
MA5-13849 targets Plasminogen in WB applications and shows reactivity with Human samples.
The MA5-13849 immunogen is human plasminogen protein.
Plasminogen is a key proenzyme of plasmin in the fibrinolytic and thrombolytic systems, the deficiency of which leads to a mild thrombotic tendency. Plasminogen binds to fibrin as well as to the surface of endothelial cells and monocytes/macrophages, where it is activated to plasmin. Streptokinase is a plasminogen activator widely used in treating blood-clotting disorders. Complexes of streptokinase with human plasminogen can hydrolytically activate other plasminogen molecules to plasmin, which then dissolves blood clots. Apolipoprotein(a) is very similar to plasminogen in terms of amino acid sequence, it inhibits plasmin generation by competing with plasminogen's binding to fibrin and endothelial cells.
Plasminogen Antibody (MA5-13849) in WB MA5-13849_WesternBlot.jpg
Western Blot with anti-Plasminogen Monoclonal Antibody [SBF1] (MA5-13849)