Perforin Antibody (5B10)

Perforin Monoclonal Antibody for IHC (P)

>> See 7 other antibodies for PRF1 (cytolysin, lymphocyte pore forming protein, lymphocyte pore-forming protein, perforin-1)
Synonyms:
cytolysin, lymphocyte pore forming protein, lymphocyte pore-forming protein, perforin-1
Entrez Gene ID:
UniProt ID:
Details
Host / Isotype: Mouse / IgG1
Class: Monoclonal
Type: Antibody
Clone: 5B10
Tested Species Reactivity: Human (Hu)
Published Species Reactivity: Human (Hu)
Immunogen: Recombinant protein corresponding to C-terminal region of human perforin
Ordering Information
Pierce Perforin Antibody (5B10)
Product #
MA5-12469
Size
500 ul
Price
$345.00
Purchase
Add Perforin Antibody (5B10) to your cart.
Tested Applications Dilution *
Immunohistochemistry (Paraffin) (IHC (P)) 1:10
Published Applications Dilution
Immunohistochemistry (IHC) See publications below
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Form Information
Form: Liquid
Storage Buffer: tissue culture supernatant
Preservative: 0.09% sodium azide
Storage Conditions: 4° C
Product Specific Information
MA5-12469 targets Perforin in IHC (P) applications and shows reactivity with Human samples.

The MA5-12469 immunogen is recombinant protein corresponding to C-terminal region of human perforin.
General Information
Perforin is a potent cytolytic pore-forming protein. It is a specific marker of functionally active cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. Perforin is a key effector mechanisms in T cell-mediated cytotoxicity. It mediates cytolysis of target cells by membrane damage and apoptosis.
Product Images
  • Perforin Antibody (MA5-12469) in IHC
    MA5-12469_Immunohistochemistry.jpg

    Immunohistochemistry with anti-Perforin Monoclonal Antibody [5B10] (MA5-12469) (MA5-12469_Immunohistochemistry.jpg)

    Immunohistochemistry with anti-Perforin Monoclonal Antibody [5B10] (MA5-12469)

    Formalin-fixed, paraffin-embedded human lymphoma stained with Perforin antibody using peroxidase-conjugate and AEC chromogen. Note granular cytoplasmic staining of lymphocytes.
Publications:
Immunohistochemistry
  Species / Dilution Summary
  Hu / Not Cited
MA5-12469 was used in immunohistochemistry to investigate the predictive value of GMP-17-positive T-lymphocytes in IgA nephropathy

Kidney Int. 2008 Jun;73(12):1426-33.
"GMP-17-positive T-lymphocytes in renal tubules predict progression in early stages of IgA nephropathy."
Author(s): van Es LA, de Heer E, Vleming LJ, van der Wal A, Mallat M, Bajema I, Bruijn JA, de Fijter JW
Number of Citations: 1
(See PubMed article )
  Hu / 0
MA5-12469 was used in immunohistochemistry to report on a case of adrenal extranodal NK/T-cell lymphoma

Diagn Cytopathol. 2009 Sep;37(9):686-95.
"Adrenal extranodal NK/T-cell lymphoma diagnosed by fine-needle aspiration and cerebrospinal fluid cytology and immunophenotyping: a case report."
Author(s): Dunning KK, Wudhikarn K, Safo AO, Holman CJ, McKenna RW, Pambuccian SE
Number of Citations: 1
(See PubMed article )
  Hu / 1:10
MA5-12469 was used in immunohistochemistry to report on a colon cancer patient treated with repeated infusions of ex vivo TKD/IL-2-activated NK cells

J Transl Med. 2009 Jun 23;7():50.
"Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy--a case report."
Author(s): Milani V, Stangl S, Issels R, Gehrmann M, Wagner B, Hube K, Mayr D, Hiddemann W, Molls M, Multhoff G
Number of Citations: 6
(See PubMed article )
  Hu / Not Cited
MA5-12469 was used in immunohistochemistry to report on two atypical cases of primary angiitis of the central nervous system

Folia Neuropathol. 2012;50(3):293-9.
"Primary angiitis of the central nervous system: 2 atypical cases."
Author(s): Pagni F, Isimbaldi G, Vergani F, Casiraghi P, Marzorati L, Migliorino G, Cattoretti G
Number of Citations: 0
(See PubMed article )
(This product is for In Vitro experimental use only. Not for resale without express authorization.)
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