This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
PDGF Receptor beta / CD140b Antibody (MA5-15143) in WB MA5-15143_WesternBlot.jpg
Western Blot with anti-PDGF Receptor beta / CD140b Monoclonal Antibody [G.290.3] (MA5-15143)
Immunofluorescent analysis of PDGF Receptor beta in NIH/3T3 cells, PDGF-treated, using a PDGF Receptor beta monoclonal antibody (Product # MA5-15143) (green). DNA is labeled using a fluorescent blue dye.
PDGF Receptor beta / CD140b Antibody (MA5-15143) in IHC MA5-15143_Immunohistochemistry.jpg
MA5-15143 was used in immunocytochemistry to study the role of hepatic stellate cells as liver-resident mesenchymal stem cells and their role in hematopoiesis
Cell Physiol Biochem. 2013;31(2-3):290-304. "Hepatic stellate cells support hematopoiesis and are liver-resident mesenchymal stem cells."
Author(s): Kordes C, Sawitza I, Götze S, Häussinger D
Number of Citations: 2
(See PubMed article )
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