PDGF Receptor beta / CD140b Antibody

PDGF Receptor beta / CD140b Polyclonal Antibody for IHC (P)

>> See 31 other antibodies for PDGFRB (CD140 antigen-like family member B, PDGF-R-beta, beta-type platelet-derived growth factor receptor)
Synonyms:
CD140 antigen-like family member B, PDGF-R-beta, beta-type platelet-derived growth factor receptor
Entrez Gene ID:
UniProt ID:
Details
Host / Isotype: Rabbit / IgG
Class: Polyclonal
Type: Antibody
Tested Species Reactivity: Human (Hu), Mouse (Ms)
Published Species Reactivity: Human (Hu)
Immunogen: A synthetic peptide derived from near the C-terminus of human PDGFR, beta
Ordering Information
Pierce PDGF Receptor beta / CD140b Antibody
Product #
PA5-16576
Size
500 ul
Price
$299.00
Purchase
Add PDGF Receptor beta / CD140b Antibody to your cart.
Tested Applications Dilution *
Immunohistochemistry (Paraffin) (IHC (P)) Assay Dependent
Published Applications Dilution
Immunohistochemistry (IHC) See publications below
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Form Information
Form: Liquid
Concentration: 1mg/ml
Purification: Protein A
Storage Buffer: PBS, pH 7.4, with 0.2% BSA
Preservative: 0.09% sodium azide
Storage Conditions: 4° C
Product Specific Information
PA5-16576 targets PDGFR beta in IHC (P) applications and shows reactivity with mouse and Human samples.

The PA5-16576 immunogen is a synthetic peptide derived from near the C-terminus of human PDGFR, beta.
General Information
PDGFR (Platelet Derived Growth Factor Receptor) exhibits two different isoforms, alpha and beta coded by two different genes. They possess five immunoglobulin like domains that are involved in ligand binding. Two tyrosine kinase domains are separated by a kinase insert to which PI-3 kinase can bind. PDGF AA can bind autophosphorylate and activate only PDGFR, alpha while PDGF BB can bind and activate to both PDGFR, alpha and beta.
Publications:
Immunohistochemistry
  Species / Dilution Summary
  Hu / 1:25
PA5-16576 was used in immunohistochemistry to report a phase 2 clinical trial of imatinib mesylate in the treatment of recurrent nonresectable chondrosarcomas

Cancer. 2011 Feb 15;117(4):826-31.
"A phase 2 trial of imatinib mesylate in patients with recurrent nonresectable chondrosarcomas expressing platelet-derived growth factor receptor-? or -?: An Italian Sarcoma Group study."
Author(s): Grignani G, Palmerini E, Stacchiotti S, Boglione A, Ferraresi V, Frustaci S, Comandone A, Casali PG, Ferrari S, Aglietta M
Number of Citations: 2
(See PubMed article )
(This product is for In Vitro experimental use only. Not for resale without express authorization.)
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