OATP2 Antibody (ESL)

OATP2 Monoclonal Antibody for Western blot, IF, IP

>> See 1 other antibody for SLCO1B1 (Organic anion transporter polypeptide 2, Solute carrier organic anion transporter family member 1B1, Solute carrier family 21 member 6Sodium-independ)
Synonyms:
Organic anion transporter polypeptide 2, Solute carrier organic anion transporter family member 1B1, Solute carrier family 21 member 6Sodium-independ
Entrez Gene ID:
UniProt ID:
Details
Host / Isotype: Mouse / IgM
Class: Monoclonal
Type: Antibody
Clone: ESL
Tested Species Reactivity: Human (Hu)
Published Species Reactivity: Human (Hu)
Immunogen: Synthetic peptide corresponding to residues E(671) S L N K N K H F V P S A G A D S E T H C(691) of human OATP2.
Ordering Information
Pierce OATP2 Antibody (ESL)
Product #
MA3-934
Size
100 µl
Price
$360.00
Purchase
Add OATP2 Antibody (ESL) to your cart.
Tested Applications Dilution *
Western Blot (WB) 1:1000
Immunofluorescence (IF) 1:100
Immunoprecipitation (IP) Assay dependent
Published Applications Dilution
Western Blot (WB) See publications below
Immunohistochemistry (IHC) See publications below
Immunoprecipitation (IP) See publications below
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Form Information
Form: Liquid
Storage Buffer: tissue culture supernatant
Preservative: 0.09% sodium azide
Storage Conditions: -20° C, Avoid Freeze/Thaw Cycles
Product Specific Information
MA3-934 detects OATP from human tissue and cells. This antibody does not detect dog, mouse or rat protein. MA3-934 shows no cross-reactivity to other OATP isoforms.

MA3-934 has been successfully used in immunofluorescence, western blotting, and immunoprecipitation procedures. Immunofluorescence staining of OATP2 in human liver samples results in a pattern consistent with plasma membrane staining.

The MA3-934 immunogen is a synthetic peptide corresponding to residues E(671) S L N K N K H F V P S A G A D S E T H C(691) of human OATP2.
General Information
The OATPs (organic anion transporter polypeptides) are a family of transport proteins that have been found to mediate the uptake of organic ions into hepatocyte cells. These proteins fall into the solute carrier family 21A (SLC21A), and are expressed in liver, kidney, and brain. These polypeptides are involved in the excretion of potentially toxic compounds and therefore play a role in the overall detoxification system of the body. Unlike other members of the OATP family, OATP2 and 8 have been detected exclusively in the liver, and there is an 80% amino acid sequence homology between these polypeptides. Other names for OATP2 include SLC21A6, OATP-C, and LST-1.
Publications:
Western Blot
  Species / Dilution Summary
  Hu / 24 ug/ml
MA3-934 was used in immunohistochemistry, immunoprecipitation and western blot to detect organic anion transporters SLC21A6 and SLC21A8 in human liver and hepatocellular carcinoma

Lab Invest. 2003 Apr;83(4):527-38.
"Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma."
Author(s): Cui Y, König J, Nies AT, Pfannschmidt M, Hergt M, Franke WW, Alt W, Moll R, Keppler D
Number of Citations: 4
(See PubMed article )
  Hu / 1:1,000
MA3-934 was used in western blot to study how the liver uptake of chenodeoxycholic acid is regulated by organic anion-transporting polypeptide (OATP) 1B1 and 1B3

J Lipid Res. 2006 Jun;47(6):1196-202.
"Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3."
Author(s): Yamaguchi H, Okada M, Akitaya S, Ohara H, Mikkaichi T, Ishikawa H, Sato M, Matsuura M, Saga T, Unno M, Abe T, Mano N, Hishinuma T, Goto J
Number of Citations: 1
(See PubMed article )
  Hu / 1:100
MA3-934 was used in western blot to identify the antibiotics able to interactg with organic anion-transporting polypeptides 1B1 and 1B3

Biol Pharm Bull. 2011;34(3):389-95.
"Screening of antibiotics that interact with organic anion-transporting polypeptides 1B1 and 1B3 using fluorescent probes."
Author(s): Yamaguchi H, Takeuchi T, Okada M, Kobayashi M, Unno M, Abe T, Goto J, Hishinuma T, Shimada M, Mano N
Number of Citations: 0
(See PubMed article )
Immunohistochemistry
  Species / Dilution Summary
  Hu / 5 ug/ml
MA3-934 was used in immunohistochemistry, immunoprecipitation and western blot to detect organic anion transporters SLC21A6 and SLC21A8 in human liver and hepatocellular carcinoma

Lab Invest. 2003 Apr;83(4):527-38.
"Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma."
Author(s): Cui Y, König J, Nies AT, Pfannschmidt M, Hergt M, Franke WW, Alt W, Moll R, Keppler D
Number of Citations: 4
(See PubMed article )
Immunoprecipitation
  Species / Dilution Summary
  Hu / Not Cited
MA3-934 was used in immunohistochemistry, immunoprecipitation and western blot to detect organic anion transporters SLC21A6 and SLC21A8 in human liver and hepatocellular carcinoma

Lab Invest. 2003 Apr;83(4):527-38.
"Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma."
Author(s): Cui Y, König J, Nies AT, Pfannschmidt M, Hergt M, Franke WW, Alt W, Moll R, Keppler D
Number of Citations: 4
(See PubMed article )
(This product is for In Vitro experimental use only. Not for resale without express authorization.)
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