Part of Thermo Fisher Scientific

MMP17 Polyclonal Antibody

MMP17 Antibody for ELISA

Synonyms:
Matrix Metallproteinase 17
Entrez Gene ID:
(Human) 23948
UniProt ID:
Q9R0S3
Details
Host / Isotype: Rabbit
Class: Polyclonal
Type: Antibody
Species Reactivity: Human (Hu) Murine (Ms)
Immunogen: Synthetic peptide of mouse MMP-17.
Ordering Information
Pierce MMP17 Polyclonal Antibody
Product Number Pkg. Size Price Purchase
GB-10042 250 µl $293.00
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This product is not available outside of the U.S.

Storage: -20º C, Avoid Freeze/Thaw Cycles
Form: 250 μl of antibody provided as crude antiserum


Applications Dilution *
ELISA (ELISA) 1:500
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Product Specific Information
GB-10042 detects MMP-17 in human and mouse samples.

GB-10042 has been successfully used in ELISA procedures.

The GB-10042 immunogen is a synthetic peptide located within the putative zinc-dependent metallopeptidases domain of mouse MMP-17.
General Information
Matrix metalloproteinases (MMPs) are believed to lay a central role in the breakdown of ECM, which is essential for embryonic development, morphogenesis, and tissue remodeling. Among these enzymes, membrane-type MMP (MT-MMP) are integral membrane protease that degrade extracellular matrix (ECM) on the cell surface, and play a major role in the activation of progelatinase A(MMP-2). Degradation of the ECM at the periphery of cells regulate cell growth, apoptosis, morphology, migration and invasion in the tissue. MMP17 (MT-MMP4) mRNA size is 2.7-kb. A minor 7.5-kb has been described. The minor one failed to express protein, while the major transcript with an extended open reading frame and expressed 67 and 71 kDa translation products. MMP17 Protein is a 518-amino acids polypeptide, which has the least degree of sequence identity to the other family membranes. The human MMP17 cDNA was found to lack the signal sequence and part of the pro-domain. Northern blot showed MMP17 to be localized in brain, colon, ovary, and testis. High level of mRNA was found in leukocyte, which suggested a possible novel function for MMP17. The distribution of MMP17 mRNA in a variety of cell line has shown MMP17 to be expressed in many transformed and non transform cell type.
(This product is for In Vitro experimental use only. Not for resale without express authorization.)