Part of Thermo Fisher Scientific

Ku70/Ku80 Monoclonal Antibody (162)

Ku70/Ku80 Antibody for FACS, IF, IHC (P), IP

Synonyms:
CTA-216E10.7, CTC75, CTCBF, G22P1, KU70, ML8, TLAA
Entrez Gene ID:
(Human) 2547
UniProt ID:
P12956
Details
Host / Isotype: Mouse / IgG2a
Class: Monoclonal
Type: Antibody
Clone: 162
Species Reactivity: Human (Hu) Non-human primate (Nhp) Amphibian (Am)
Immunogen: Human B cell nuclei from plasmacytoid 2p68 cells.
Ordering Information
Pierce Ku70/Ku80 Monoclonal Antibody (162)
Product Number Pkg. Size Price Purchase
MA1-21818 500 µl $327.00
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Storage: 4º C
Form: 500 µl of (0.2 mg/ml) antibody in 10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide


Applications Dilution *
Immunofluorescence (IF) Assay dependent
Immunoprecipitation (IP) 2µg/mg
Flow Cytometry (FACS) Assay dependent
Immunohistochemistry (Paraffin) (IHC (P)) 1 µg/ml
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Product Specific Information
MA1-21818 detects Ku70/Ku80 in human, non-human primate, and amphibian samples. This antibody will detect Ku70/Ku80 from mouse and rat samples in IP only. MA1-21818 is not recommended for Western blot procedures.

MA1-21818 has been successfully used in FACS, immunofluorescence, immunohistochemistry (paraffin), and immunoprecipitation procedures.

The MA1-21818 immunogen is human B cell nuclei from plasmacytoid 2p68 cells.
General Information
The Ku autoantigen is a heterodimer of 70 kDa (p70) and ~80 kDa (p80) proteins. The p70 / p80 dimer is important for function of a 460 kDa DNA-dependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
(This product is for In Vitro experimental use only. Not for resale without express authorization.)