KCNQ5 Antibody

KCNQ5 Polyclonal Antibody for Western blot

Synonyms:
rCG_43583, Kcnq5
Entrez Gene ID:
Details
Host / Isotype: Rabbit
Class: Polyclonal
Type: Antibody
Tested Species Reactivity: Rat (Rt)
Published Species Reactivity: Rat (Rt)
Immunogen: Synthetic peptide corresponding to residues C(880) K A G E S T D A L S L P H V K L K(897) of human KCNQ5 protein.
Ordering Information
Pierce KCNQ5 Antibody
Product #
PA1-941
Size
200 µg
Price
$250.00
Purchase
Add KCNQ5 Antibody to your cart.
Tested Applications Dilution *
Western Blot (WB) 1:250
Published Applications Dilution
Western Blot (WB) See publications below
Immunohistochemistry (IHC) See publications below
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Form Information
Form: Liquid
Concentration: 1mg/ml
Purification: Antigen affinity chromatography
Storage Buffer: PBS with 1mg/ml BSA
Preservative: 0.05% sodium azide
Storage Conditions: -20° C, Avoid Freeze/Thaw Cycles
Product Specific Information
PA1-941 detects the KCNQ5 from rat samples. This antibody is specific for KCNQ5 and does not detect KCNQ1, KCNQ2, KCNQ3 or KCNQ4.

PA1-941 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~125 kDa band representing KCNQ5 from rat brain extract.

The PA1-941 immunizing peptide corresponds to amino acid residues 880-897 from human KCNQ5.
General Information
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system. Studies have shown that KCNQ3 and KCNQ5 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.

Voltage-dependent potassium channels are key regulators of the resting membrane potential and modulate the excitability of electrically active cells. The channels are usually tetrameric and can interact with auxiliary subunits that enhance or modify currents mediated by the pore-forming subunits.
Publications:
Western Blot
  Species / Dilution Summary
  Rt / Not Cited
PA1-941 was used in immunohistochemistry and western blot to investigate the distribution of ion channels expressed within the sensory nerve terminals in the rat carotid body

J Comp Neurol. 2008 Oct 1;510(4):367-77.
"Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body."
Author(s): Buniel M, Glazebrook PA, Ramirez-Navarro A, Kunze DL
Number of Citations: 1
(See PubMed article )
Immunohistochemistry
  Species / Dilution Summary
  Rt / 1:500
PA1-941 was used in immunohistochemistry to investigate the role of KCNQ/M-current on arterial baroreceptor function at the sensory terminal in rats

J Physiol. 2008 Feb 1;586(3):795-802.
"The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats."
Author(s): Wladyka CL, Feng B, Glazebrook PA, Schild JH, Kunze DL
Number of Citations: 1
(See PubMed article )
  Rt / Not Cited
PA1-941 was used in immunohistochemistry and western blot to investigate the distribution of ion channels expressed within the sensory nerve terminals in the rat carotid body

J Comp Neurol. 2008 Oct 1;510(4):367-77.
"Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body."
Author(s): Buniel M, Glazebrook PA, Ramirez-Navarro A, Kunze DL
Number of Citations: 1
(See PubMed article )
(This product is for In Vitro experimental use only. Not for resale without express authorization.)
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