KCNQ5 Antibody

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KCNQ5 Polyclonal Antibody for Western blot

Synonyms:

rCG_43583, Kcnq5

Entrez Gene ID:

(Rat) 259273

Details

Host / Isotype:	Rabbit
Class:	Polyclonal
Type:	Antibody
Species Reactivity:	Rat (Rt)
Immunogen:	Synthetic peptide corresponding to residues C(880) K A G E S T D A L S L P H V K L K(897) of human KCNQ5 protein.

Ordering Information
Pierce KCNQ5 Antibody

Product #

PA1-941

Size

200 µg

Price

$239.00

Purchase

Bulk Order?

Storage:	-20° C, Avoid Freeze/Thaw Cycles
Form:	1 mg/ml Epitope Affinity Purified IgG in PBS with 1 mg/ml BSA and 0.05% sodium azide.

Applications	Dilution *

Western Blot (WB)	1:250
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Product Specific Information

PA1-941 detects the KCNQ5 from rat samples. This antibody is specific for KCNQ5 and does not detect KCNQ1, KCNQ2, KCNQ3 or KCNQ4.

PA1-941 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~125 kDa band representing KCNQ5 from rat brain extract.

The PA1-941 immunizing peptide corresponds to amino acid residues 880-897 from human KCNQ5.

General Information

KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system. Studies have shown that KCNQ3 and KCNQ5 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.

Voltage-dependent potassium channels are key regulators of the resting membrane potential and modulate the excitability of electrically active cells. The channels are usually tetrameric and can interact with auxiliary subunits that enhance or modify currents mediated by the pore-forming subunits.

PubMed References:

IHC (2)
WB (1)

Immunohistochemistry
	Species / Dilution	Summary
	Rt / 1:500	PA1-941 was used in immunohistochemistry to investigate the role of KCNQ/M-current on arterial baroreceptor function at the sensory terminal in rats J Physiol. 2008 Feb 1;586(3):795-802. "The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats." Author(s): Wladyka CL, Feng B, Glazebrook PA, Schild JH, Kunze DL Number of Citations: 1 (See PubMed article )
	Rt / Not Cited	PA1-941 was used in immunohistochemistry and western blot to investigate the distribution of ion channels expressed within the sensory nerve terminals in the rat carotid body J Comp Neurol. 2008 Oct 1;510(4):367-77. "Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body." Author(s): Buniel M, Glazebrook PA, Ramirez-Navarro A, Kunze DL Number of Citations: 1 (See PubMed article )

Western Blot
	Species / Dilution	Summary
	Rt / Not Cited	PA1-941 was used in immunohistochemistry and western blot to investigate the distribution of ion channels expressed within the sensory nerve terminals in the rat carotid body J Comp Neurol. 2008 Oct 1;510(4):367-77. "Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body." Author(s): Buniel M, Glazebrook PA, Ramirez-Navarro A, Kunze DL Number of Citations: 1 (See PubMed article )

(This product is for In Vitro experimental use only. Not for resale without express authorization.)