* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
TBS, pH 8.0,
Product Specific Information
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
MA1-35230 was used in immunohistochemistry to identity the CD44posCD49fhiCD133/2hi cells as tumorigenic in murine xenograft models
Cancer Res. 2010 Jun 1;70(11):4624-33. "CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer."
Author(s): Meyer MJ, Fleming JM, Lin AF, Hussnain SA, Ginsburg E, Vonderhaar BK
Number of Citations: 6
(See PubMed article )
(This product is for In Vitro experimental use only. Not for resale without express authorization.)