* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
PBS, pH 7.4,
0.09% sodium azide
Product Specific Information
MA5-12032 targets Insulin in immunohistochemistry (paraffin) applications and shows reactivity with human samples.
The MA5-12032 immunogen is swine insulin.
Insulin is a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell of islets of Langerhans and tumor (insulinoma) marker.
Insulin Antibody (MA5-12032) in IHC MA5-12032_Immunohistochemistry.jpg
Immunohistochemistry with anti-Insulin Monoclonal Antibody [INS04 (E2-E3)] (MA5-12032)
MA5-12032 was used in immunohistochemistry to study mitochondrial and cytosolic oxidative stress in streptozotocin-diabetic mouse pancreas and the effect of combined antioxidant therapy
Exp Toxicol Pathol. 2013 Mar;65(3):255-62. "The potential role of combined antioxidant treatment on pancreas of STZ-diabetic mice."
Author(s): Karatug A, Bolkent S
Number of Citations: 1
(See PubMed article )
(This product is for In Vitro experimental use only. Not for resale without express authorization.)