ITM2B Antibody

ITM2B Polyclonal Antibody for Western blot, IF, ICC, IHC (P)

>> See 2 other antibodies for ITM2B (ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, ABri/ADan amyloid peptide, BRICHOS domain containing 2B, transmembrane protein BRI)
Synonyms:
ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, ABri/ADan amyloid peptide, BRICHOS domain containing 2B, transmembrane protein BRI
Entrez Gene ID:
UniProt ID:
Details
Host / Isotype: Rabbit / IgG
Class: Polyclonal
Type: Antibody
Tested Species Reactivity: Human (Hu), Mouse (Ms)
Immunogen: Recombinant fragment corresponding to a region within amino acids 15 and 264 of Human ITM2B
Ordering Information
Pierce ITM2B Antibody
Product #
PA5-31441
Size
100 µL
Price
$324.00
Purchase
Tested Applications Dilution *
Western Blot (WB) 1:500-1:3000
Immunofluorescence (IF) 1:100-1:1000
Immunocytochemistry (ICC) 1:100-1:1000
Immunohistochemistry (Paraffin) (IHC (P)) 1:100-1:1000
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Form Information
Form: Liquid
Concentration: 0.93mg/ml
Purification: Antigen affinity chromatography
Storage Buffer: PBS, pH 7, with 1% BSA, 20% glycerol
Preservative: 0.01% thimerosal
Storage Conditions: -20° C, Avoid Freeze/Thaw Cycles
Product Specific Information
PA5-31441 targets ITM2B in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.

The PA5-31441 immunogen is recombinant fragment corresponding to a region within amino acids 15 and 264 of Human ITM2B.
General Information
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
Product Images
  • ITM2B Antibody (PA5-31441) in WB
    PA5-31441_WB_2.jpg

    Western Blot with anti-ITM2B Polyclonal Antibody (PA5-31441) (PA5-31441_WB_2.jpg)

    Western Blot with anti-ITM2B Polyclonal Antibody (PA5-31441)

    Western blot analysis of ITM2B using 30µg of A) HepG2 and B) HCT116 lysate. Samples were loaded onto a 12% SDS-PAGE gel and probed with an ITM2B polyclonal antibody (Product # PA5-31441) at a dilution of 1:1000.
  • ITM2B Antibody (PA5-31441) in WB
    PA5-31441_WB_1.jpg

    Western Blot with anti-ITM2B Polyclonal Antibody (PA5-31441) (PA5-31441_WB_1.jpg)

    Western Blot with anti-ITM2B Polyclonal Antibody (PA5-31441)

    Western blot analysis of ITM2B using 50 µg mouse brain lysate. Samples were loaded onto a 12% SDS-PAGE gel and probed with an ITM2B polyclonal antibody (Product # PA5-31441) at a dilution of 1:1000.
  • ITM2B Antibody (PA5-31441) in IF
    PA5-31441_IF.jpg

    Immunofluorescence with anti-ITM2B Polyclonal Antibody (PA5-31441) (PA5-31441_IF.jpg)

    Immunofluorescence with anti-ITM2B Polyclonal Antibody (PA5-31441)

    Immunofluorescent analysis of ITM2B in methanol-fixed HeLa cells using an ITM2B polyclonal antibody (Product # PA5-31441) at a 1:200 dilution.
  • ITM2B Antibody (PA5-31441) in IHC (P)
    PA5-31441_IHC.jpg

    Immunohistochemistry (Paraffin) with anti-ITM2B Polyclonal Antibody (PA5-31441) (PA5-31441_IHC.jpg)

    Immunohistochemistry (Paraffin) with anti-ITM2B Polyclonal Antibody (PA5-31441)

    Immunohistochemical analysis of ITM2B in the Golgi apparatus of paraffin-embedded mouse brain stem tissue using an ITM2B polyclonal antibody (Product # PA5-31441) at a dilution of 1:500.
(This product is for In Vitro experimental use only. Not for resale without express authorization.)
Part of Thermo Fisher Scientific