* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Antigen affinity chromatography
PBS, pH 7,
1% BSA, 20% glycerol
-20° C, Avoid Freeze/Thaw Cycles
Product Specific Information
PA5-31441 targets ITM2B in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-31441 immunogen is recombinant fragment corresponding to a region within amino acids 15 and 264 of Human ITM2B.
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
ITM2B Antibody (PA5-31441) in WB ITM2B_PA5-31441_Antibody_WesternBlot.jpg
Western Blot with anti-ITM2B Polyclonal Antibody (PA5-31441)