|Host / Isotype:||Rabbit / IgG|
|Species Reactivity:||Bovine (Bv)|
|Immunogen:||Recombinant IL-1 beta|
|Pierce IL-1 beta Antibody|
|Form:||1 mg of purified antibody by Protein G affinity chromatography then Lyophilized, preservative and carrier free|
|ELISA (ELISA)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
|Product Specific Information|
|PBOIL1BI targets IL-1 beta in ELISA applications and shows reactivity with Bovine samples.
The PBOIL1BI immunogen is recombinant IL-1 beta.
PBOIL1BI detects IL-1 beta which has a predicted molecular weight of approximately 18 kDa.
|The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.|
|Species / Dilution||Summary|
Bv / 5 ug/ml
PBOIL1BI was used in ELISA to investigate the inflammatory response to a bovine intramammary challenge with a persistent strain of Escherichia coli during late gestation
J Dairy Sci. 2012 Jan;95(1):117-26.
"Bovine intramammary Escherichia coli challenge infections in late gestation demonstrate a dominant antiinflammatory immunological response."
Author(s): Quesnell RR, Klaessig S, Watts JL, Schukken YH
Number of Citations: 0
(See PubMed article )