Dysferlin Antibody (MA5-12568) in IHC
MA5-12568_Immunohistochemistry.jpgFormalin-fixed, paraffin-embedded human skeletal muscle stained with Dysferlin antibody using peroxidase-conjugate and AEC chromogen. Note membrane staining of muscle fibers.
|Host / Isotype:||Mouse / IgG1|
|Tested Species Reactivity:||Human (Hu), Mouse (Ms), Rat (Rt), Canine (Ca), Hamster (Hm), Porcine (Po), Rabbit (Rb)|
|Published Species Reactivity:||Mouse (Ms), Rat (Rt)|
|Immunogen:||A synthetic peptide corresponding to aa1999-2016 of human dysferlin|
|Pierce Dysferlin Antibody (Ham1/7B6)|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:20|
|Immunohistochemistry (IHC)||See publications below|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
|Storage Buffer:||tissue culture supernatant|
|Preservative:||0.09% sodium azide|
|Storage Conditions:||4° C|
|Product Specific Information|
|MA5-12568 targets Dysferlin in IHC (P) applications and shows reactivity with Canine, Hamster, Human, mouse, Porcine, Rabbit, and Rat samples.
The MA5-12568 immunogen is a synthetic peptide corresponding to aa1999-2016 of human dysferlin.
|Dysferlin is a muscular plasma membrane protein which is defective in Limb-Girdle Muscular Dystrophy type 2B (LGMD2B) and Miyoshi Myopathy (MM).|
|Species / Dilution||Summary|
Ms / 0
MA5-12568 was used in immunohistochemistry to compare the localization of cardiomyocyte dysferlin in normal and dysferlin-deficient A/J mice and its effect on the development of cardiomyopathy
Am J Pathol. 2009 Dec;175(6):2299-308.
"Dysferlin deficiency and the development of cardiomyopathy in a mouse model of limb-girdle muscular dystrophy 2B."
Author(s): Chase TH, Cox GA, Burzenski L, Foreman O, Shultz LD
Number of Citations: 1
(See PubMed article )
Rt / Not Cited
MA5-12568 was used in immunohistochemistry to study the molecular and cellular mechanisms contributing to the skeletal muscle side effects of the antibiotic daptomycin.
Muscle Nerve. 2010 Sep;42(3):385-93.
"Characterization of skeletal muscle effects associated with daptomycin in rats."
Author(s): Kostrominova TY, Hassett CA, Rader EP, Davis C, Larkin LM, Coleman S, Oleson FB, Faulkner JA
Number of Citations: 0
(See PubMed article )