Part of Thermo Fisher Scientific

Dynein Intermediate chain Monoclonal Antibody (70.1)

Dynein Intermediate chain Antibody for ELISA, ICC, IF, IP, Western blot

Synonyms:
RP11-296L22.2, CILD1, ICS, ICS1, MGC26204, PCD
Entrez Gene ID:
(Human) 27019
UniProt ID:
Q9UI46
Details
Host / Isotype: Mouse / IgM
Class: Monoclonal
Type: Antibody
Clone: 70.1
Species Reactivity: Human (Hu) Marsupial (Mr) Deer (Dr) Rat (Rt) Hamster (Hm) Chicken (Ck) Amphibian (Am)
Immunogen: Cytoplasmic, full length, native, chicken dynein intermediate chain protein purified from chick brain.
Ordering Information
Pierce Dynein Intermediate chain Monoclonal Antibody (70.1)
Product Number Pkg. Size Price Purchase
MA1-22146 100 µl $365.00
Add Dynein Intermediate chain Monoclonal Antibody (70.1) to your cart.


Storage: -20º C, Avoid Freeze/Thaw Cycles
Form: 100 µl of ascites with 15mM sodium azide.


Applications Dilution *
Western Blot (WB) 1/2000
Immunocytochemistry (ICC) Assay dependent
ELISA (ELISA) Assay dependent
Immunofluorescence (IF) Assay dependent
Immunoprecipitation (IP) Assay dependent
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Product Specific Information
MA1-22146 detects Dynein intermediate chains in human, indian muntjac (deer), rat, frog, chicken, marsupial, and hamster samples. This antibody is know to detect cytoplasmic Dynein intermediate chains, and reactivity with the axonemal form is not known.

MA1-22146 has been successfully used in ELISA, immunocytochemistry, immunofluorescence, immunoprecipitation and Western blot procedures. By Western blot, MA1-22146 detects a ~ 70 kDa triplet representing the Dynein intermediate chains.

The MA1-22146 immunogen is cytoplasmic, full length, native, chicken dynein intermediate chain protein purified from chick brain.
General Information
Eukaryotic cells rely on actin and microtubule-based protein ""motors"" to generate intracellular movements. These protein ""motors"" contain specialized domains that hydrolyze ATP to produce force and movement along a cytoskeletal polymer (actin in the case of myosin family and microtubules in the case of the kinesin family and dyneins). Dynein has been implicated in cytoplasmic motile functions, including chromosomal movement, retrograde organelle and axonal transport, the endocytic pathway, and the organization of the Golgi apparatus. In all cell types, dynein has the same basic structures and is composed of two or three distinct heavy chains (~450 kD), three intermediate chains (70-125 kD), and at least four light chains (15-25 kD).
(This product is for In Vitro experimental use only. Not for resale without express authorization.)