Part of Thermo Fisher Scientific

Cytochrome c Monoclonal Antibody (7H8.2C12)

Cytochrome c Antibody for IHC (P), Western blot

Synonyms:
cytochrome c
Entrez Gene ID:
(Human) 54205
UniProt ID:
P99999
Details
Host / Isotype: Mouse / IgG2b, kappa
Class: Monoclonal
Type: Antibody
Clone: 7H8.2C12
Species Reactivity: Human (Hu) Murine (Ms) Rat (Rt) Canine (Ca) Equine (Eq) Amphibian (Am) Drosophila (Dm) Avian (Av)
Immunogen: Synthetic peptides corresponding to amino acids 1-80, 81-104 and 66-104 of pigeon cytochrome c
Ordering Information
Pierce Cytochrome c Monoclonal Antibody (7H8.2C12)
Product Number Pkg. Size Price Purchase
MA5-11674 500 ul $296.00
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Storage: 4º C, DO NOT FREEZE!
Form: 500 ul of antibody purified from the ascites fluid by Protein A chromatography (200 ug/ml). Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.


Applications Dilution *
Immunohistochemistry (Paraffin) (IHC (P)) 1-2 µg/ml
Western Blot (WB) Assay Dependent
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Product Specific Information
MA5-11674 targets Cytochrome c in IHC (P) and WB applications and shows reactivity with Amphibian, Avian, Canine, Drosophila, Equine, Human, Murine, and Rat samples.

The MA5-11674 immunogen is synthetic peptides corresponding to amino acids 1-80, 81-104 and 66-104 of pigeon cytochrome c.
General Information
Cytochrome c is an electron transporting protein that resides within the inter-membrane space of the mitochondria, where it plays a critical role in the process of oxidative phosphorylation and production of cellular ATP. An increasing amount of interest has been directed toward the role which cytocrome c has been demonstrated to play in apoptotic processes. Following exposure to apoptotic stimuli, cytochrome c is rapidly released from the mitochondria into the cytosol, an event which may be required for the completion of apoptosis in some systems. Cytosolic cytochrome c functions in the activation of caspase-3, and ICE family molecule that is a key effector of apoptosis.
Product Images
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    Immunohistochemistry with anti-Cytochrome c Monoclonal Antibody [7H8.2C12] (MA5-11674)

    Immunohistochemistry with anti-Cytochrome c Monoclonal Antibody [7H8.2C12] (MA5-11674)

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    Formalin-fixed, paraffin-embedded human heart stained with cytochrome c antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of cardiac muscle.
     
 
 
(This product is for In Vitro experimental use only. Not for resale without express authorization.)