Part of Thermo Fisher Scientific

Complement C1s Monoclonal Antibody (9)

Complement C1s Antibody for ELISA

Synonyms:
C1 esterase, Complement C1s subcomponent
Entrez Gene ID:
(Human) 716
UniProt ID:
P09871
Details
Host / Isotype: Mouse / IgG1
Class: Monoclonal
Type: Antibody
Clone: 9
Species Reactivity: Human (Hu)
Immunogen: C1s proenzyme purified from human plasma.
Ordering Information
Pierce Complement C1s Monoclonal Antibody (9)
Product Number Pkg. Size Price Purchase
ABS 002-09-02 200 µg $362.00
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Storage: 4º C
Form: 200 µg of Protein A/G purified antibody (1 mg/ml) in 0.01 M phosphate buffer, with 0.5 M NaCl and 15 mM sodium azide; pH 7.4.


Applications Dilution *
ELISA (ELISA) 1:20,000
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Product Specific Information
ABS 002-09-02 is specific for C1s proenzyme and activated free C1s.

ABS 002-09-02 has been successfully used in ELISA procedures. ABS 002-09-02 reacts in ELISA when tested with activated C1s enzyme directly coated onto the microtiter well or in sandwich ELISA in combination with a polyclonal antibody in coat.

The ABS 002-09-02 immunogen is C1s proenzyme purified from human plasma.

Epitope of ABS 002-09-02 differs from that of ABS 002-49-02.
General Information
C1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2.
(This product is for In Vitro experimental use only. Not for resale without express authorization.)