Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C
Product Specific Information
CYP27B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
CYP27B1 Antibody (PA5-26065) in WB CYP27B1-_Antibody_PA5-26065_WB_1_112013.jpg
Western Blot with anti-CYP27B1 Polyclonal Antibody (PA5-26065)
Immunohistochemistry analysis in formalin-fixed, paraffin-embedded human kidney tissue using a CYP27B1 polyclonal antibody (Product # PA5-26065), followed by HRP-conjugated secondary antibody and DAB staining.
CYP27B1 Antibody (PA5-26065) in FACS CYP27B1-_Antibody_PA5-26065_FC_1_112013.jpg
Flow Cytometry with anti-CYP27B1 Polyclonal Antibody (PA5-26065)
Flow cytometry analysis of 293 cells using a CYP27B1 polyclonal antibody (Product # PA5-26065) (right) compared to a negative control cell (left) at a dilution of 1:10-50, followed by a FITC-conjugated goat anti-rabbit antibody
(This product is for In Vitro experimental use only. Not for resale without express authorization.)