| Details | |
| Host / Isotype: | Rabbit / IgG |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Mouse (Ms) Rabbit (Rb) Non-human primate (Nhp) |
| Immunogen: | synthetic peptide FLARHRVTSYTS, corresponding to amino acids 330-341 of Human CXCR1. |
| Ordering Information | ||||
| Pierce CXCR1 Antibody |
| Storage: | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Form: | 100 ug of Protein G purified antibody (0.5 mg/ml) in PBS with 0.2% gelatin and 0.05% sodium azide. |
| Applications | Dilution * |
| Western Blot (WB) | 1-3 µg/ml |
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* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
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| Product Specific Information |
| PA1-29466 detects CXCR1 from mouse, human samples. It is also expected to react with chimpanzee, gorilla, and rabbit due to sequence homology. PA1-29466 has been successfully used in Western blot applications. Predicted molecular weight: 42 kDa. The PA1-29466 immunogen is: Synthetic peptide: FLARHRVTSYTS, corresponding to amino acids 330-341 of Human CXCR1. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| General Information |
| The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. |