* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Antigen affinity chromatography
0.05% sodium azide
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Specific Information
PA5-23062 reacts with CX3CL1 in human and mouse samples.
PA5-23062 has been successfully used in Immunocytochemistry/Immunofluorescence and Immunohistochemistry applications.
The PA5-23062 immunogen is a genomic peptide made to an internal region of the human CX3CL protein (within residues 20-150).
CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively, (1-4). The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 (5). Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine (6). CX3CR1 mediates leukocyte migration and adhesion (5). CX3CR1 is expressed in a variety of human tissues and cell lines (2).
CX3CL1 Antibody (PA5-23062) in IF PA5-23062_Immunofluorescence.jpg
Immunofluorescence with anti-CX3CL1 Polyclonal Antibody (PA5-23062)