Part of Thermo Fisher Scientific

CGRP alpha Monoclonal Antibody (5)

CGRP alpha Antibody for ELISA, IHC

Synonyms:
Calcitonin gene-related peptide
Entrez Gene ID:
(Human) 796
UniProt ID:
P06881
Details
Host / Isotype: Mouse / IgG1, kappa
Class: Monoclonal
Type: Antibody
Clone: 5
Species Reactivity: Human (Hu) Rat (Rt)
Immunogen: Synthetic peptide corresponding to residues 1-18 of human alpha-CGRP.
Ordering Information
Pierce CGRP alpha Monoclonal Antibody (5)
Product Number Pkg. Size Price Purchase
ABS 026-05-02 200 µl $534.00
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Storage: 4º C, store in dark
Form: 200 ul of protein A/G purified antibody (1 mg/ml) in 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl with 15mM sodium azide.


Applications Dilution *
Immunohistochemistry (IHC) 1:400
ELISA (ELISA) 1:2000
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Product Specific Information
ABS 026-05-02 detects CGRP alpha in human and rat samples. ABS 026-05-02 binds human alpha-CGRP. Based on inhibition ELISA, this antibody shows full cross-reactivity with rat alpha-CGRP and about about 50% cross-reactivity with human beta-CGRP. Cross-reactivity with coated rat alpha-CGRP is low (8%) and there is no cross-reaction with human amylin.

ABS 026-05-02 has been successfully used in ELISA and immunohistochemistry procedures.

ABS 026-05-02 immunogen is a synthetic peptide corresponding to residues 1-18 of human alpha-CGRP
General Information
Calcitonin gene-related peptide is a 37 amino-acid vasoactive neuropeptide (mw 3789) widely expressed throughout the central and peripheral nervous system. CGRP has potent vasodilatory effects probably serving as a regulator of regional blood flow, in addition to a variety of other cellular effects.
PubMed References:
ELISA
  Species / Dilution Summary
  Hu / Not Cited
 ABS 026-05-02 was used in ELISA to study the role of mitochondrial pathway in neutrophil survival
J Immunol. 2007 Feb 15;178(4):2535-41.
"IgE modulates neutrophil survival in asthma: role of mitochondrial pathway."
Author(s): Saffar AS, Alphonse MP, Shan L, Hayglass KT, Simons FE, Gounni AS
Number of Citations: 4
(See PubMed article )
(This product is for In Vitro experimental use only. Not for resale without express authorization.)