* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Form information is not available for this product.
Product Specific Information
MS1746S targets CD62P in IHC applications and shows reactivity with Human samples.
The MS1746S immunogen is recombinant complement control protein domain of P-Selection.
MS1746S detects CD62P which has a predicted molecular weight of approximately 86 kDa.
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.
MS1746S was used in immunohistochemistry to examine the prognostic significance of maspin, E-selectin, and P-selectin in papillary thyroid carcinomas
Pathol Res Pract. 2008;204(10):743-50. "Maspin, E-selectin, and P-selectin expressions in papillary thyroid carcinomas and their correlation with prognostic parameters."
Author(s): Bal N, Kocer NE, Ertorer ME, Canpolat ET, Kayaselcuk F
Number of Citations: 1
(See PubMed article )
(This product is for In Vitro experimental use only. Not for resale without express authorization.)