* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
TBS, pH 8.0,
Product Specific Information
MA1-35230 detects CD49f in human samples.
MA1-35230 has been successfully used in immunohistochemistry, flow cytometry and immunofluorescence applications.
The MA1-35230 immunogen is from the CD49f antigen.
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
MA1-35230 was used in immunohistochemistry to identity the CD44posCD49fhiCD133/2hi cells as tumorigenic in murine xenograft models
Cancer Res. 2010 Jun 1;70(11):4624-33. "CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer."
Author(s): Meyer MJ, Fleming JM, Lin AF, Hussnain SA, Ginsburg E, Vonderhaar BK
Number of Citations: 6
(See PubMed article )
(This product is for In Vitro experimental use only. Not for resale without express authorization.)