MA5-14843 targets FGF Receptor 3 in ICC, IHC (P), IP, and WB applications and shows reactivity with Human samples.
The MA5-14843 immunogen is gST-FGFR-3 cytoplasmic domain fusion protein.
MA5-14843 detects FGF Receptor 3 which has a predicted molecular weight of approximately 165 kDa, 145 kDa and 125 kDa .
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
CD333 / FGFR3 Antibody (MA5-14843) in WB MA5-14843_WesternBlot.jpg
Western Blot with anti-CD333 / FGFR3 Monoclonal Antibody [T.994.9] (MA5-14843)
Western blot analysis of FGF Receptor 3 in recombinant human FGFR-3 cytoplasmic fragment proteins (lane 1) and extracts from KMS-11 cells (lane 2) using FGF Receptor 3 monoclonal antibody (Product # MA5-14843).
CD333 / FGFR3 Antibody (MA5-14843) in IF MA5-14843_Immunofluorescence.jpg
Immunofluorescence with anti-CD333 / FGFR3 Monoclonal Antibody [T.994.9] (MA5-14843)