This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy.
Beta-IG-H3 Antibody (PA5-17189) in WB PA5-17189_WesternBlot.jpg
Western Blot with anti-Beta-IG-H3 Polyclonal Antibody (PA5-17189)
Immunofluorescent analysis of Beta-IG-H3 in A549 cells, TGF-beta-treated, using a Beta-IG-H3 polyclonal antibody (Product # PA5-17189) (green). Actin filaments are labeled with a fluorescent red phalloidin. DNA is labeled using a fluorescent blue dye.
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