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MA3-020 detects endothelin (ET)-1, ET-2 and ET-3. This antibody shows no cross-reactivity with the peptides ET(15-20) and ET(15-22).
MA3-020 has been successfully used in ELISA procedures. By ELISA this antibody is useful in solid-phase or competitive solution based procedures particularly in the study of enzymatic processing of ET, and in the identification of putative enzyme inhibitors. MA3-020 can detect approximately 0.5 pmol/ml ET-1 by direct ELISA.
The MA3-020 immunogen is a synthetic peptide corresponding to residues C(15) H L D I I W(21) of endothelin. This sequence is conserved between numerous species.
Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms- ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart, and liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Big endothelin-1; Endothelin-1; Endothelin-2; Endothelin-3; ET-1; ET-2; ET-3; PPET1; PPET2; PPET3; preproendothelin 2; Preproendothelin-1; Preproendothelin-2; Preproendothelin-3
Gene Aliases: EDN1; EDN2; EDN3
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