* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Form information is not available for this product.
Product Specific Information
PA1-84108 detects Amyloid Pre. Protein, C-Terminal in human and primate samples.
PA1-84108 has been successfully used in immunohistochemistry (Frozen sections), Western blot and immunoprecipitation applications.
The immunogen used to produce PA1-84108 is from a synthetic peptide from C-terminus of APP.
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
(This product is for In Vitro experimental use only. Not for resale without express authorization.)