* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Antigen affinity chromatography
0.05% sodium azide
-20° C, Avoid Freeze/Thaw Cycles
Product Specific Information
PA1-16975 detects ATP13A2 in human and mouse samples.
PA1-16975 has been successfully used in Western blot and IHC procedures. By Western blot, PA1-16975 detects a ~128 kDa protein representing ATP13A2.
The PA1-16975 immunizing peptide is a synthetic peptide corresponding to residues 200-300 of human ATP13A2.
Neurodegenerative disorders such as Parkinson and Alzheimer disease cause motor and cognitive dysfunction and belong to a heterogeneous group of common and disabling disorders. ATP13A2 is a neuronal P-type ATPase gene underlying an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia. ATP13A2 protein is located in the membrane of these lysosomes and is formed most strongly in the brain, especially in the substantia nigra, a brain region which is known to play a central role in Parkinson’s disease.
ATP13A2 Antibody (PA1-16975) in WB PA1-16975_Westernblot.jpg
Western Blot with anti-ATP13A2 Polyclonal Antibody (PA1-16975)