Metargidin; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; MDC-15; A disintegrin and metalloproteinase domain 15; ADAM 15; ADAM15; MDC15
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C
100 µg (0.25 mg/ml) in PBS with 0.09% (W/V) sodium azide.
Western Blot (WB)
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Product Specific Information
PA5-14324 targets ADAM15 in WB applications and shows reactivity with Human samples. The PA5-14324 immunogen is a synthetic peptide from the center region of ADAM15 conjugated to KLH. PA5-14324 detects ADAM15 which has a predicted molecular weight of approximately 88 kDa.
The protein encoded by this gene is a member of the ADAM protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
ADAM15 Antibody (PA5-14324) in WB
Western Blot with anti-ADAM15 Polyclonal Antibody (PA5-14324)