Part of Thermo Fisher Scientific

ABCC2 Monoclonal Antibody (M2III-6)

ABCC2 Antibody for ICC, IHC

Synonyms:
MRP2
Entrez Gene ID:
(Human) 1244
UniProt ID:
Q92887
Details
Host / Isotype: Mouse / IgG2a
Class: Monoclonal
Type: Antibody
Clone: M2III-6
Species Reactivity: Human (Hu)
Immunogen: Fusion protein of cMOAB/MRP2.
Ordering Information
Pierce ABCC2 Monoclonal Antibody (M2III-6)
Product Number Pkg. Size Price Purchase
MA1-35676 1 ml $478.00
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Storage: -20º C, Avoid Freeze/Thaw Cycles
Form: 1 ml serum-free tissue culture supernatant (250 µg immunoglobµlin/ml) in 0.7% BSA and 0.1% sodium azide.


Applications Dilution *
Immunocytochemistry (ICC) 1:20
Immunohistochemistry (IHC) 1:20
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Product Specific Information
MA1-35676 detects ABCC2 in human samples.

MA1-35676 has been successfully used in immunohistochemistry and immunocytochemistry applications.

The MA1-35676 immunogen is from a bacterial fusion protein of cMOAB/MRP2, containing the 202-amino acid COOH terminal end of the protein.
General Information
ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
(This product is for In Vitro experimental use only. Not for resale without express authorization.)