Part of Thermo Fisher Scientific

ABCB11 Polyclonal Antibody

ABCB11 Antibody for Western blot, IHC

Entrez Gene ID:
(Human) 8647
UniProt ID:
O95342
Details
Host / Isotype: Rabbit
Class: Polyclonal
Type: Antibody
Species Reactivity: Human (Hu ) Murine (Ms )
Immunogen: Synthetic peptide from the C-terminal region of ABCB11 conjugated to KLH.
Ordering Information
Pierce ABCB11 Polyclonal Antibody
Product Number Pkg. Size Price Purchase
PA5-13105 100 µg $299.00
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Storage: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Form: 100 µg (0.25 mg/ml) in PBS with 0.09% (W/V) sodium azide.


Applications Dilution *
Immunohistochemistry (IHC) 1:50-1:100
Western Blot (WB) 1:100-1:500
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Product Specific Information
PA5-13105 targets ABCB11 in WB and IHC applications and shows reactivity with Human and Mouse samples. The PA5-13105 immunogen is a synthetic peptide from the C-terminal region of ABCB11 conjugated to KLH. PA5-13105 detects ABCB11 which has a predicted molecular weight of approximately 146 kDa.
General Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
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References:
Chen, H.L., et al., J. Pediatr. 140(1):119-124 (2002).
Saito, S., et al., J. Hum. Genet. 47(1):38-50 (2002).
Strautnieks, S.S., et al., Nat. Genet. 20(3):233-238 (1998).
(This product is for In Vitro experimental use only. Not for resale without express authorization.)