DKC1 Antibody
DKC1 Polyclonal Antibody for IF, IHC, Western blot
Synonyms:
CBF5, DKC, DKCX, NAP57, NOLA4, XAP101, CBF5 homolog, H/ACA ribonucleoprotein complex subunit 4, cbf5p homolog, nopp140-associated protein of 57 kDa, nucleolar protein NAP57, nucleolar protein family A member 4, snoRNP protein DKC1
Entrez Gene ID:
UniProt ID:
O60832
| Details | |
| Host / Isotype: | Rabbit / IgG |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Mouse (Ms) |
| Immunogen: | Synthetic peptide from the Central region of human DKC1 conjugated to KLH. |
| Ordering Information | ||||
| Pierce DKC1 Antibody |
| Storage: | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C |
| Form: | 100 ug of antibody purified through a protein A column followed by peptide affinity purification (0.25 mg/ml) in PBS with 0.09% (W/V) sodium azide. |
| Applications | Dilution * |
| Western Blot (WB) | 1:100-500 |
| Immunohistochemistry (IHC) | 1:50-100 |
| Immunofluorescence (IF) | 1:10-50 |
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* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
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| Product Specific Information |
| PA5-25393 targets DKC1 in IF, IHC, and WB applications and shows reactivity with Human and Murine samples. The PA5-25393 immunogen is synthetic peptide from the Central region of human DKC1 conjugated to KLH. |
| General Information |
| This gene is a member of the H/ACA snoRNPs gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. |
| Product Images |
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DKC1 Antibody (PA5-25393) in IF
Immunofluorescence with anti-DKC1 Polyclonal Antibody (PA5-25393)
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DKC1 Antibody (PA5-25393) in IHC
Immunohistochemistry with anti-DKC1 Polyclonal Antibody (PA5-25393)
Immunohistochemical analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. -
DKC1 Antibody (PA5-25393) in WB
Western Blot with anti-DKC1 Polyclonal Antibody (PA5-25393)
Western blot analysis of DKC1 in mouse testis tissue lysates using 35ug per lane of antibody.
(This product is for In Vitro experimental use only. Not for resale without express authorization.)
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DKC1 Antibodies > DKC1 Polyclonal Antibody PA5-25393
