SDHB Antibody
SDHB Polyclonal Antibody for ICC, IF, IHC (P), Western blot
Synonyms:
IP, PGL4, SDH, SDH1, SDH2, SDHIP, iron-sulfur subunit of complex II, succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Entrez Gene ID:
UniProt ID:
P21912
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Mouse (Ms) |
| Immunogen: | A synthetic peptide made to an N-terminal region of the human SDHB protein (within residues 1-150). |
| Ordering Information | ||||
| Pierce SDHB Antibody |
| Storage: | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Form: | 100 ul of Antigen affinity chromatography purified antibody (0.57 mg/ml) in PBS with 30% glycerol and 0.05% Sodium azide. |
| Applications | Dilution * |
| Immunocytochemistry (ICC) | 1:50-1:100 |
| Immunofluorescence (IF) | 1:50-1:100 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50-1:100 |
| Western Blot (WB) | 1:7000 |
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* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
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| Product Specific Information |
| PA5-23079 reacts with SDHB in human and murine samples. The target sequence has 92% identity to rat, cow and pig, 85% identity to Xenopus and 84% identity to Zebrafish. PA5-23079 has been successfully used in Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry and Immunohistochemistry-Paraffin applications. The PA5-23079 immunogen is a genomic peptide made to an N-terminal region of the human SDHB protein (within residues 1-150). |
| General Information |
| Part of the succinate dehydrogenase complex, SDHB is a mitochondrial protein that interfaces with the catalysis of succinate dehydrogenase. In many gastrointestinal tumors, SDHB is irregularly expressed, and leads to mutational activation of KIT. This may be as a result of elevated oxidative stress caused by mitochondrial dysfunction. In Dutch populations, there is a higher prevalence of mutations in the SDHB gene, and a higher overall level of hereditary paraganglioma and pheochromocytoma syndromes than in other Europeans. Similar trends in mutations in this gene seem to be related to atherosclerosis in American populations. Overall, the SDHB protein effects multiple cellular metabolism processes and it is not surprisingly linked to metabolism-related cellular dysfunctions. |
| Product Images |
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SDHB Antibody (PA5-23079) in IF
Immunofluorescence with anti-SDHB Polyclonal Antibody (PA5-23079)
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SDHB Antibody (PA5-23079) in IHC
Immunohistochemistry with anti-SDHB Polyclonal Antibody (PA5-23079)
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SDHB Antibody (PA5-23079) in WB
Western Blot with anti-SDHB Polyclonal Antibody (PA5-23079)
(This product is for In Vitro experimental use only. Not for resale without express authorization.)
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SDHB Antibodies > SDHB Polyclonal Antibody PA5-23079
