* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
0.09% sodium azide
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C
Product Specific Information
PA5-11640 targets GJB6 in WB and IHC applications and shows reactivity with Human samples. The PA5-11640 immunogen is a synthetic peptide from the N-terminal region of GJB6 conjugated to KLH. PA5-11640 detects GJB6 which has a predicted molecular weight of approximately 30 kDa.
Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.
GJB6 Antibody (PA5-11640) in IHC
Immunohistochemistry with anti-GJB6 Polyclonal Antibody (PA5-11640)