| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Synthetic Peptide: V(1) Y L S E C K T G I G N G Y R G T M S(19) |
| Ordering Information | ||||
| Pierce Angiostatin Antibody |
| Storage: | -20° C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µg of epitope affinity purified IgG (1 mg/ml) in PBS containing 1 mg/ml BSA and 0.05% sodium azide. |
| Applications | Dilution * |
| Western Blot (WB) | 2 µg/ml |
|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
|
|
| Product Specific Information |
| PA1-600 detects recombinant human angiostatin. PA1-600 has been successfully used in Western blot procedures. By Western blot, this antibody detects a 50 kDa protein representing recombinant human angiostatin. PA1-600 immunizing peptide corresponds to amino acid residues 1-19 from mouse angiostatin. This sequence is 95% and 84% conserved in rat and human angiostatin, respectively. |
| General Information |
| Angiostatin is a proteolytic fragment that comprises the first four kringle domains of the ~85 kDa plasminogen. Angiostatin reduces endothelial cell proliferation and acts as an potent inhibitor of angiogenesis and tumor growth. |