Cytochrome P450 1A1 Antibody
Cytochrome P450 1A1 Polyclonal Antibody for Western blot
Synonyms:
CYP, P450, CYPIA1, P450-P1, P450 form 6, P450-C
Entrez Gene ID:
UniProt ID:
(Hu) P04798
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Purified, His-tagged, full length human P450 1A1 fusion protein. |
| Ordering Information | ||||
| Pierce Cytochrome P450 1A1 Antibody |
| Storage: | -20° C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µl of purified IgG in PBS containing 0.05% sodium azide. |
| Applications | Dilution * |
| Western Blot (WB) | 1:500 |
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* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
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| Product Specific Information |
| PA1-340 detects cytochrome P450 (P450) 1A1 from human cells. This antibody detects, to a lesser extent, other P450 isoforms. PA1-340 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~54 kDa protein representing P450 1A1 from MCF-7 cell extract. The PA1-340 immunogen is purified, His-tagged, full length human P450 1A1 fusion protein. |
| General Information |
| The cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as nicotinamide adenine dinucleotide phosphate (NADPH) and P450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega-hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). As well as fatty acid metabolism, P450s also metabolize many drugs and toxins. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin. |
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Cytochrome P450 1A1 Antibody (PA1-340) in WB
Western Blot with anti-Cytochrome P450 1A1 Polyclonal Antibody (PA1-340)
Western blot detection of cytochrome P450 1A1 from MCF-7 cell extract using PA1-340.
| PubMed References: |
| Western Blot | ||
| Species / Dilution | Summary | |
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Hu / Not Cited |
PA1-340 was used in western blot to evaluate an in vitro model of pancreatic carcinogenesis
Toxicol Lett. 2011 Apr 10;202(1):15-22.
"A novel in vitro pancreatic carcinogenesis model." Author(s): Kang HJ, Hong YB, Kim HJ, Yi YW, Nath RG, Chang YS, Cho HC, Bae I Number of Citations: 1 (See PubMed article  )
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Hu / Not Cited |
PA1-340 was used in western blot to investigate the involvement of BRCA1 in the prevention and repair of DNA damage
Toxicol Sci. 2011 Jul;122(1):26-37.
"Detoxification: a novel function of BRCA1 in tumor suppression?" Author(s): Kang HJ, Hong YB, Kim HJ, Rodriguez OC, Nath RG, Tilli EM, Albanese C, Chung FL, Kwon SH, Bae I Number of Citations: 1 (See PubMed article )
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(This product is for In Vitro experimental use only. Not for resale without express authorization.)
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Cytochrome P450 1A1 Antibodies > Cytochrome P450 1A1 Polyclonal Antibody PA1-340
