* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Product Specific Information
MA5-16034 reacts with Telomerase reverse transcriptase in human and murine samples.
MA5-16034 has been successfully used in Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin and Immunoprecipitation applications.
The MA5-16034 immunogen is a full-length recombinant human Telomerase reverse transcriptase from insect cells.
Telomeres are nucleoprotein structures at the ends of eukaryotic chromosomes. They regulate several crucial cellular functions and participate in the control of complex phenotypes, such as aging and cancer. Cell immortalization is strongly associated with the stabilization of telomere length. Therefore, it is suggested that cancer cells achieve immortalization in part through illegitimate activation of telomerase expression. hTERT (TERT) is the rate-limiting catalytic subunit of telomerase.
Telomerase is an enzyme uniquely associated with immortal cell lines and is useful for identifying undifferentiated PSCs.
Telomerase reverse transcriptase Antibody (MA5-16034) in IHC
Immunohistochemistry with anti-Telomerase reverse transcriptase Monoclonal Antibody [2C4] (MA5-16034)